Powassan and other emerging neuroinvasive arboviruses in North America

Purpose of review Arthropod-borne viruses (arboviruses) represent a group of pathogens with increasing global relevance, some of which cause neuroinvasive disease. Transmitted by arthropod vectors and maintained by a variety of primary and amplifying hosts, epidemics are dependent on numerous environmental and anthropogenic factors. This review serves to highlight several important neuroinvasive arboviruses relevant to North America and discuss the neurologic presentations, diagnosis, outcomes, and future trends. Recent findings Recent shifts in the epidemiology and ecology of arboviruses in North America include the divergence of arboviruses such as dengue and chikungunya from dependence on enzootic cycles, the geographical expansion of Oropouche virus, and the increasing incidence of some established North American arboviruses such as Powassan virus. Accurate identification of the factors contributing to arboviral outbreaks is critical to improve preventive public health measures. Similarly, further elucidating the relevant pathogen and host factors that determine neuroinvasiveness, neurotropism, and neurovirulence will be key to the development of successful vaccines and targeted therapeutics. Summary Arboviruses are an important pathogen relevant to human disease. Familiarity with the presentations, diagnostic workup, treatment and preventive strategies, and expected course is critical for clinicians caring for these patients.