1344-P: Systemic Inflammation Response Index Independently Associated with Increased Mortality in Individuals with Metabolic Syndrome—Results from the NHANES Prospective Cohort Study

Introduction and Objective: This study aimed to investigate the relationship between the systemic inflammation response index (SIRI) as well as the all-cause and cardiovascular disease mortality in American adults diagnosed with metabolic syndrome (MetS). Methods: A prospective cohort study was conducted using data from the 2007-2018 National Health and Nutrition Examination Survey (NHANES). SIRI = (neutrophil count × monocyte count)/lymphocyte count. Cox proportional hazard models were used to evaluate the association between SIRI and all-cause and cardiovascular mortality. Subgroup analyses were performed to confirm the robustness of the findings. Restricted cubic spline (RCS) analysis was used to explore potential nonlinear relationships. Results: A total of 3,431 individuals aged 20 years or older with MetS were included in the study. During a mean follow-up of 88.97 months, 494 all-cause deaths and 132 cardiovascular-related deaths were recorded. In fully adjusted models, each unit increase in SIRI was associated with a 15% higher risk of all-cause mortality (HR = 1.15, 95% CI: 1.07-1.22, p < 0.001) and a 16% higher risk of cardiovascular mortality (HR = 1.16, 95% CI: 1.05-1.29, p = 0.004). Subgroup analyses revealed no significant interactions between SIRI and subgroups (p > 0.050). RCS analysis indicated a linear relationship between SIRI and both all-cause mortality and cardiovascular mortality. Conclusion: SIRI was an independent predictor of all-cause and cardiovascular mortality in patients with MetS. SIRI holds promise as a biomarker for long-term follow-up in this population. Disclosure J. Guo: None. K. Mutailipu: None. X. Wen: None. J. Yin: None. H. Chen: None. S. Qu: None. L. Bu: None.