Exploring the Chemical Constituents, Antioxidant, Xanthine Oxidase and COX Inhibitory Activity of Commiphora gileadensis Commonly Grown Wild in Saudi Arabia

化学 咖啡酸 黄嘌呤氧化酶 橙皮苷 抗氧化剂 没食子酸 槲皮素 芦丁 抗菌剂 食品科学 白杨素 传统医学 抗坏血酸 多酚 儿茶素 生物化学 类黄酮 有机化学 替代医学 病理 医学
作者
Khalid A. Shadid,Ashok K. Shakya,Rajashri R. Naik,Talal Salem Al‐Qaisi,Ghaleb A. Oriquat,Ali M. Atoom,Husni S. Farah
出处
期刊:Molecules [Multidisciplinary Digital Publishing Institute]
卷期号:28 (5): 2321-2321 被引量:11
标识
DOI:10.3390/molecules28052321
摘要

The use of the synthetic drugs has increased in the last few decades; however, these drugs exhibit various side effects. Scientists are therefore seeking alternatives from natural sources. Commiphora gileadensis has long been used to treat various disorders. It is commonly known as bisham or balm of Makkah. This plant contains various phytochemicals, including polyphenols and flavonoids, with biological potential. We found that steam-distilled essential oil of C. gileadensis exhibited higher antioxidant activity (IC50, 22.2 µg/mL) than ascorbic acid (IC50, 1.25 µg/mL). The major constituents (>2%) in the essential oil were β-myrcene, nonane, verticiol, β-phellandrene, β-cadinene, terpinen-4-ol, β-eudesmol, α-pinene, cis-β-copaene and verticillol, which might be responsible for the antioxidant and antimicrobial activity against Gram-positive bacteria. The extract of C. gileadensis exhibited inhibitory activity against cyclooxygenase (IC50, 450.1 µg/mL), xanthine oxidase (251.2 µg/mL) and protein denaturation (110.5 µg/mL) compared to standard treatments, making it a viable treatment from a natural plant source. LC-MS analysis revealed the presence of phenolic compounds such as caffeic acid phenyl ester, hesperetin, hesperidin, chrysin and transient amounts of catechin, gallic acid, rutin and caffeic acid. The chemical constituents of this plant can be explored further to investigate its wide variety of therapeutic potential.
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