姜黄素
自愈水凝胶
化学
生物利用度
乙二醇
控制释放
环糊精
溶解度
傅里叶变换红外光谱
色谱法
化学工程
材料科学
有机化学
纳米技术
药理学
生物化学
医学
工程类
作者
Ljubiša Nikolić,Maja Urošević,Vesna Nikolić,Ivana Gajić,Ana Tačić,Vojkan Miljković,Slavko Rakić,Sanja Đokić,Jelena Kesić,Snežana Ilić‐Stojanović,Goran Nikolić
出处
期刊:Pharmaceutics
[MDPI AG]
日期:2023-01-22
卷期号:15 (2): 382-382
被引量:4
标识
DOI:10.3390/pharmaceutics15020382
摘要
Curcumin comes from the plant species Curcuma longa and shows numerous pharmacological activities. There are numerous curcumin formulations with gels or cyclodextrins in order to increase its solubility and bioavailability. This paper presents the formulation of complex of curcumin with 2-hydroxypropyl-β-cyclodextrin in a thermosensitive hydrogel, based on N-isopropylmethacrylamide and N-isopropylacrylamide with ethylene glycol dimethacrylate as a crosslinker. The product was characterized by chemical methods and also by FTIR, HPLC, DSC, SEM, XRD. The results show that synthesis was successfully done. With an increase in the quantity of crosslinker in the hydrogels, the starting release and the release rate of curcumin from the formulation of the complex with hydrogels decreases. The release rate of curcumin from the gel complex formulation is constant over time. It is possible to design a formulation that will release curcumin for more than 60 days. In order to determine the mechanism and kinetics of curcumin release, various mathematical models were applied by using the DDSolver package for Microsoft Excel application. The Korsmeyer-Peppas model best describes the release of curcumin from the gel formulation of the complex, while the values for the diffusion exponent (0.063–0.074) shows that mechanism of the release rate is based on diffusion.
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