Chondrocyte secretome enriched microparticles encapsulated with the chondrocyte membrane to facilitate the chondrogenesis of BMSCs and reduce hypertrophy

The “artificial chondrocytes” that consist of chondrocyte secretome enriched PLGA microparticles with the encapsulation of chondrocytes’ membrane fragments had facilitated chondrogenesis and reduced hypertrophy of BMSCs in vitro and in vivo .