胶质瘤
芳香烃受体
癌变
癌症研究
免疫系统
转录因子
医学
生物
癌症
生物信息学
免疫学
内科学
基因
生物化学
作者
Ting Xiang Lim,Muneer Ahamed,David C. Reutens
标识
DOI:10.1016/j.drudis.2021.09.021
摘要
Glioblastoma multiforme (GBM) is a deadly disease; 5-year survival rates have shown little improvement over the past 30 years. In vivo positron emission tomography (PET) imaging is an important method of identifying potential diagnostic and therapeutic molecular targets non-invasively. The aryl hydrocarbon receptor (AhR) is a transcription factor that regulates multiple genes involved in immune response modulation and tumorigenesis. The AhR is an attractive potential drug target and studies have shown that its activation by small molecules can modulate innate and adaptive immunity beneficially and prevent AhR-mediated tumour promotion in several cancer types. In this review, we provide an overview of the role of the AhR in glioma tumorigenesis and highlight its potential as an emerging biomarker for glioma therapies targeting the tumour immune response and PET diagnostics.
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