区域选择性
分子内力
模块化设计
化学
组合化学
戒指(化学)
立体化学
四克隆
催化作用
计算机科学
有机化学
程序设计语言
作者
Burdge He,Takayoshi Oguma,Takahiro Kawajiri,Ryan A. Shenvi
标识
DOI:10.26434/chemrxiv.8263415.v1
摘要
The first synthesis of GB22 was accomplished by a con- cise, modular route. Two building blocks converged in a novel sp3-sp2 attached-ring coupling that used Ir/Ni dual-catalysis to reverse the regioselectivity of siloxycy- clopropane arylation. This cross-coupling proved general to access β-substituted tetralones via ring-expansion of indanone-derived siloxycyclopropanes. The congested, bridging rings of the GB alkaloids were completed using an aluminum-HFIP complex that effected intramolecular cyclization of an acid-labile substrate.
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