情绪障碍
自闭症
菌群(微生物学)
肠道菌群
病理生理学
心情
精神科
双相情感障碍
医学
自闭症谱系障碍
心理学
生物
免疫学
内科学
细菌
焦虑
遗传学
出处
期刊:Brain and nerve
日期:2021-08-01
卷期号:73 (8): 871-877
标识
DOI:10.11477/mf.1416201854
摘要
The intestinal flora plays a key role in the stress response and barrier function of the gut, both of which are closely associated with the pathophysiology of mental health conditions, such as mood disorders and autistic spectrum disorder through the phenomenon of brain-gut interaction. Despite increasing accumulation of empirical data regarding the contribution of the gut microbiota to these disorders, studies have reported inconsistent results. Notably, short chain fatty acid-producing bacteria and those implicated in the pathophysiology of metabolic diseases appear to be associated with the psychiatric conditions. Clinical trials have shown some evidence to suggest the beneficial effects of probiotics in depressive and neurodevelopmental disorders. Limited studies have discussed this subject; however, the role of the intestinal flora in the pathophysiology and treatment of mental disorders appears to be a promising field of research.
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