低语长廊波浪
材料科学
检出限
等离子体子
表面等离子共振
灵敏度(控制系统)
光电子学
波长
共振(粒子物理)
光学
纳米技术
谐振器
纳米颗粒
化学
物理
电子工程
色谱法
粒子物理学
工程类
作者
Yihua Hao,Zhixiong Guo
出处
期刊:Journal of The Optical Society of America B-optical Physics
[The Optical Society]
日期:2021-09-13
卷期号:38 (10): 2855-2855
被引量:6
摘要
Surface plasmonic resonance (SPR) is integrated into a whispering-gallery mode (WGM) optical microsensor to augment sensitivity in this study. The performance of such WGM silica ring sensors of 20 µm in size with an Ag or Au metal core was evaluated for detection of small respiratory viruses such as COVID-19 via the finite-element modeling. Compared with pure WGM sensors, the integration with SPR enhances sensitivity by 3–5 times and facilitates combination with the polymerase chain reaction method to achieve fast, accurate, and specific virus detection. The presence of a single respiratory virus of 70 to 100 nm in diameter in air environment could shift the sensor resonance wavelength by 36 to 64 pm in the case of an Au metal core or by 34 to 63 pm of an Ag metal core. With use of a general-purpose optical analyzer of 10 pm resolution, a single airborne virus of 20 nm in size is detectable using the proposed hybrid sensor. This corresponds to about 0.005 vol. %. For viruses in aqueous solution, the detection limit rises to about 0.2 vol. %. A fundamental enhancement factor based on relative electric energy ratio is introduced and defined to analyze and quantify sensitivity enhancement for the first time, to the best of our knowledge.
科研通智能强力驱动
Strongly Powered by AbleSci AI