电催化剂
电化学
乳酸脱氢酶
过渡金属
化学
氢氧化物
生物传感器
无机化学
双金属片
电解质
金属
催化作用
电极
核化学
酶
生物化学
有机化学
物理化学
作者
Yuting Wu,Po-Kai Tsao,Kuan‐Jung Chen,Yu-Chi Lin,Sofiannisa Aulia,Ling-Yu Chang,Kuo‐Chuan Ho,Chih Hsiang Chang,Hitoshi Mizuguchi,Min–Hsin Yeh
标识
DOI:10.1016/j.snb.2021.130505
摘要
Lactate concentration in the human body is the crucial index to be monitored for evaluating exercise levels under anaerobic metabolism conditions. To solve the unstable nature of enzymes in biosensors for lactate detection, in this study, Ni-based layered double hydroxide (LDH) with various secondary transition metals (Fe and Co) was proposed as electrocatalysts in an enzyme-free electrochemical lactate sensor. According to the mechanism of lactate oxidation on the transition metal-based electrocatalyst, secondary transition metal of Co could serve as the active site for lactate oxidation and facilitate the adsorption of OH− in the alkaline electrolyte. After exploring the influence of secondary metal in Ni-based LDH, NiCo LDH modified screen-printed carbon electrodes (SPCEs) reached the high sensitivity of 30.59 ± 0.34 μA mM-1 cm-2 at an applied potential of 0.55 V (vs. Ag/AgCl KCl sat’d) in the concentration range from 5 to 25 mM, which is relatively higher than pristine Ni LDH (23.51 ± 0.45 μA mM-1 cm-2) and NiFe LDH (3.03 ± 0.06 μA mM-1 cm-2). This study proposes a new category of electrocatalyst to be utilized in enzyme-free electrochemical lactate sensors with reliable and stable performance as one of the non-invasive biosensors.
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