每1
诱导剂
报告基因
基因
白细胞介素1β
生物
细胞生物学
时钟
白细胞介素
生物钟
细胞因子
遗传学
基因表达
作者
Dirk Motzkus,Urs Albrecht,Erik Maronde
标识
DOI:10.1385/jmn:18:1-2:105
摘要
The mammalian period (Per) genes which are components of the circadian clock are mainly regulated via an autoregulatory feedback loop. Here we show that a human PER1 (hPER1) reporter gene activity is stimulated by interleukin-6 (IL-6), a member of the large cytokine gene family and an inducer of the acute phase reaction, in human hepatoma (HuH-7) cells. Our results confirm and extend the view that the hPER1 promoter acts as a sensor for multiple signaling molecules thereby integrating different physiological parameters.
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