Adjunctive Glucocorticoid Therapy in Patients with Septic Shock

Sepsis has been identified by the WHO as a global health priority, however, there has been no proven pharmacologic treatment other than the appropriate antibiotic agents, fluids and vasopressors as required. Reported death rates among hospitalized patients with sepsis range between 30-45% (22). Glucocorticoids have been used as an adjuvant therapy for septic shock for more than 40 years, however, uncertainty remains about their safety and efficacy (23).