甲酸脱氢酶
醇脱氢酶
化学
生物结合
固定化酶
纳米技术
乳酸脱氢酶
脱氢酶
酶
磁性纳米粒子
纳米颗粒
生物化学
材料科学
纳米医学
组合化学
辅因子
作者
Samaneh Jafari Porzani,Adriana Sturion Lorenzi,Masoumeh Eghtedari,Bahareh Nowruzi
出处
期刊:Mini-reviews in Medicinal Chemistry
[Bentham Science]
日期:2020-11-19
卷期号:20
被引量:7
标识
DOI:10.2174/1570193x17666201119152944
摘要
: The general overview aimed to increase the current knowledge interactions between dehydrogenase enzymes and nanoparticles, and introduce dehydrogenases for industrial and health purposes. Nanoparticles (NPs) are particles constituting from 1 to 100 nm based on their size with a surrounding interfacial layer. Nanoparticle-Protein interactions include covalent and non-covalent attachments. Several dehydrogenase enzymes (e.g., alcohol dehydrogenase, lactate dehydrogenase, alanine dehydrogenase, glutamate dehydrogenase, leucine dehydrogenase, phenylalanine dehydrogenase, and malate dehydrogenase) are used for immobilization by nanoparticles. Such as magnetic nanoparticles and quantum dots, represent attractive model systems for biological enzyme assemblies and design of bioanalytical sensors. Further, bioconjugation of nanoparticles with dehydrogenase enzymes has broad applications in biocatalysis and nanomedicine for drug discovery. However, studies on the characterization of nanoparticle-enzyme complexes accept apparent that the anatomy and action of enzymes are afflicted by the chemistry of nanoparticle ligand, size, actual, and labeling methods. Moreover, the nanoparticle-protein conjugation revealed increased/decreased enzymatic activity due to nanoparticle features. Thus, this work reviewed the findings of nanoparticle-enzyme interactions for nanotechnology applications and conjugation techniques. We also highlight several challenges associated with the nanoparticle-enzyme interactions, including stability and reusability of the enzymes in nanoparticle-enzyme formation.
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