作者
S. Horsefield,H. Burdett,Xiaoxiao Zhang,M.K. Manik,Yun Shi,Jian Chen,Tiancong Qi,Jonathan Gilley,Jhih-Siang Lai,Maxwell X. Rank,Lachlan W. Casey,Weixi Gu,Daniel Ericsson,Gabriel Foley,Robert Hughes,Todd Bosanac,Mark von Itzstein,John P. Rathjen,J.D. Nanson,Mikael Bodén,Ian B. Dry,Simon J. Williams,Brian J. Staskawicz,Michael P. Coleman,Thomas Ve,Peter N. Dodds,Bostjan Kobe
摘要
NAD depletion as pathogen response One way that plants respond to pathogen infection is by sacrificing the infected cells. The nucleotide-binding leucine-rich repeat immune receptors responsible for this hypersensitive response carry Toll/interleukin-1 receptor (TIR) domains. In two papers, Horsefield et al. and Wan et al. report that these TIR domains cleave the metabolic cofactor nicotinamide adenine dinucleotide (NAD + ) as part of their cell-death signaling in response to pathogens. Similar signaling links mammalian TIR-containing proteins to NAD + depletion during Wallerian degeneration of neurons. Science , this issue p. 793 , p. 799