疾病
p38丝裂原活化蛋白激酶
地图14
癌症
蛋白激酶A
激酶
化学
计算生物学
神经科学
医学
生物
生物化学
内科学
MAP激酶激酶激酶
作者
Moustafa M. Madkour,Hanan S. Anbar,Mohammed I. El–Gamal
标识
DOI:10.1016/j.ejmech.2021.113216
摘要
P38α (which is also named MAPK14) plays a pivotal role in initiating different disease states such as inflammatory disorders, neurodegenerative diseases, cardiovascular cases, and cancer. Inhibitors of p38α can be utilized for treatment of these diseases. In this article, we reviewed the structural and biological characteristics of p38α, its relationship to the fore-mentioned disease states, as well as the recently reported inhibitors and classified them according to their chemical structures. We focused on the articles published in the literature during the last decade (2011–2020).
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