Pathogenesis of diabetic cardiomyopathy

Diabetic cardiomyopathy,one of the most serious complications of diabetes mellitus,is an independent specific cardiomyopathy.The damage of ventricular diastolic function and cardiac insufficiency are the most common symptoms.The complexity of pathogenesis comprise energy metabolic disorder,apoptosis,oxidative stress,the cardiac interstitial fibrosis,microvascular lesion and cardiac autonomic neuropathy.Clinically,some diabetic patients under the strict control of blood glucose still developed diabetic cardiomyopathy.Therefore,further to explore the pathogenesis of diabetic cardiomyopathy may help to provide a new approach for the prevention and treatment of diabetic cardiomyopathy. Key words: Diabetes mellitus;  Cardiomyopathy;  Pathogenesis