Focoxanthin Supplementation Reduces Body Fat in Over Weight Humans-A Randomized, Placebo Controlled Study-

Fucoxanthin, a xantophyll carotenoid contained in marine foods, has been shown accelerates lipolysis of adipose tissue in cells and animals studies, although the efficacy is unclear in humans. The present study investigated the effect of fucoxanthin supplementation on body weight and abdominal fat in healthy human subjects with higher body mass index. A randomized, placebo-controlled clinical trial was performed in 19 subjects who were divided into 3 groups; placebo, fucoxanthin 2 mg╱day, and fucoxanthin 4 mg╱day groups. During 3 months of administration, the body weight of the 4 mg╱day group showed a significant reduction in all 3 months of administration period compared with the initial baseline although there was no significant difference in the placebo and 2 mg╱day groups through the administration period. Both 2 and 4 mg╱day groups showed a significant reduction of weight loss rate compared with the placebo group, and morereduction was found in 4 mg╱day group. The abdominal fat area was positively correlated with body weight loss. These results suggested that supplementation of fucoxanthin accelerates weight loss with reducing visceral fat.