化学
三氟甲基
试剂
格氏试剂
镁
酮
产量(工程)
有机化学
卤化物
格氏反应
药物化学
苯
氯化物
烷基
冶金
材料科学
作者
Jiro Nakatani,Tatsuhiro Nozoe
标识
DOI:10.1021/acs.oprd.6b00200
摘要
The effect of LiCl-promoted insertion of magnesium turnings into halogenated-trifluoromethylbenzenes for Grignard reagent synthesis was investigated. In the presence of less than 1.0 equiv of LiCl, chloro(trifluoromethyl)benzene Grignard reagents were easily generated. The 2-trifluoromethylphenyl magnesium chloride Grignard reagent was obtained in high yield and 2′-trifluoromethyl-substituted aromatic ketone was synthesized through reaction of the obtained Grignard reagent with a carboxylic anhydride in an 83% yield.
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