四克隆
立体选择性
化学
戒指(化学)
反应性(心理学)
羟醛反应
芳基
组合化学
分子
立体化学
有机化学
催化作用
医学
病理
替代医学
烷基
作者
Stanley Chang,Michael Holmes,Jeffrey Mowat,Michael Meanwell,Robert Britton
标识
DOI:10.1002/anie.201608449
摘要
Abstract α‐Arylcyclobutanones display unique reactivity that makes them valuable synthetic intermediates and target molecules. We describe the preparation of α‐aryl‐ and α‐heteroarylcyclobutanones through a direct α‐arylation reaction. Problematic fragmentations are avoided by the use of LiO t Bu, which promotes a rapid but reversible self‐aldol reaction that slowly releases the enolate required for α‐arylation. We also demonstrate the ring expansion of α‐arylcyclobutanones, a process that is highlighted in the stereoselective synthesis of 1‐methoxy coniothyrinone D.
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