A 45-year-old woman with a cutaneous lupus without antiphospholipid antibody, treated by prophylactic anticoagulation, presented with an acute and severe painless vision loss of the left eye. Central retinal artery occlusion (CRAO) was diagnosed on ophthalmologic examination (figure 1). MRI suggested a primitive inflammation of the ophthalmic artery (figure 2). There was no evidence of a cardiac or carotid emboli or a vasculitis. She was treated with antiaggregant without success.