蛋白磷酸酶2
磷酸酶
蛋白质亚单位
丝氨酸
生物
基因亚型
PTPN11型
苏氨酸
DUSP6型
功能(生物学)
癌症研究
磷酸化
癌症
细胞生物学
生物化学
作者
Ziming Mao,Chunying Liu,Xuejing Lin,Bin Sun,Changqing Su
标识
DOI:10.1016/j.canlet.2017.11.024
摘要
Abstract Protein phosphatase 2, regulatory subunit B (B56), alpha isoform (PPP2R5A) is one of the regulatory subunits of the protein phosphatase 2A (PP2A), which is a major member of protein serine/threonine phosphatases in cells. PPP2R5A can regulate the cellular location, substrate specification and protein phosphatase function of PP2A, through which PPP2R5A plays an important role in many cellular activities. It has been reported that PPP2R5A relates with many diseases including some kinds of cancers, but the related mechanisms have a lot remaining to be discovered or demonstrated. This review arms to summarize PPP2R5A and its relationships with the occurrence and progression of tumors, helping us to further understand its significance in the prevention, early diagnosis, targeted therapy and prognosis improvement of tumors.
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