利拉鲁肽
医学
安慰剂
降钙素
内科学
糖尿病
内分泌学
胃肠病学
随机对照试验
2型糖尿病
泌尿科
病理
替代医学
作者
László Hegedűs,Steven I. Sherman,R. Michael Tuttle,Bernt Johan von Scholten,Søren Rasmussen,Julie Derving Karsbøl,Gilbert H. Daniels
出处
期刊:Diabetes Care
[American Diabetes Association]
日期:2017-12-26
卷期号:41 (3): 620-622
被引量:31
摘要
OBJECTIVE To describe the changes in serum levels of calcitonin in liraglutide- and placebo-treated patients in the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results—A Long Term Evaluation (LEADER) trial over a 3.5–5-year period. RESEARCH DESIGN AND METHODS Patients (n = 9,340) with type 2 diabetes and high risk for cardiovascular events were randomized 1:1 to liraglutide or placebo. We analyzed calcitonin levels, thyroid and C-cell adverse events, and neoplasms. RESULTS At 36 months, patients randomized to liraglutide versus placebo showed no evidence of increase in calcitonin concentrations in male (estimated treatment ratio [ETR] 1.03 [95% CI 1.00, 1.06]; P = 0.068) and female (ETR 1.00 [95% CI 0.97, 1.02]; P = 0.671) subgroups. There were no episodes of C-cell hyperplasia or medullary thyroid carcinoma in liraglutide-treated patients. CONCLUSIONS There was no evidence of a difference in calcitonin concentrations between the liraglutide and placebo groups, and no C-cell malignancies occurred in the liraglutide group.
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