T细胞受体
细胞生物学
机械转化
T细胞
压电1
化学
信号转导
卡尔帕因
生物
免疫系统
受体
免疫学
机械敏感通道
生物化学
离子通道
酶
作者
Chinky Shiu Chen Liu,Deblina Raychaudhuri,Barnali Paul,Yogaditya Chakrabarty,Amrit Raj Ghosh,Oindrila Rahaman,Arindam Talukdar,Dipyaman Ganguly
出处
期刊:Journal of Immunology
[The American Association of Immunologists]
日期:2018-02-15
卷期号:200 (4): 1255-1260
被引量:105
标识
DOI:10.4049/jimmunol.1701118
摘要
Abstract TCRs recognize peptides on MHC molecules and induce downstream signaling, leading to activation and clonal expansion. In addition to the strength of the interaction of TCRs with peptides on MHC molecules, mechanical forces contribute to optimal T cell activation, as reflected by the superior efficiency of immobilized TCR–cross-linking Abs compared with soluble Abs in TCR triggering, although a dedicated mechanotransduction module is not identified. We found that the professional mechanosensor protein Piezo1 is critically involved in human T cell activation. Although a deficiency in Piezo1 attenuates downstream events on ex vivo TCR triggering, a Piezo1 agonist can obviate the need to immobilize TCR–cross-linking Abs. Piezo1-driven Ca2+ influx, leading to calpain activation and organization of cortical actin scaffold, links this mechanosensor to optimal TCR signaling. Thus, we discovered a hitherto unknown regulatory mechanism for human T cell activation and provide the first evidence, to our knowledge, for the involvement of Piezo1 mechanosensors in immune regulation.
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