化学
尼妥珠单抗
联氨(抗抑郁剂)
共轭体系
单克隆抗体
锝
抗体
组合化学
放射化学
核化学
有机化学
色谱法
免疫学
医学
聚合物
作者
María Fernanda García,Victoria Calzada,Ximena Camacho,Enzo Goicochea,Juan Gambini,Thomas P. Quinn,Williams Porcal,Pablo Cabral
出处
期刊:Current Radiopharmaceuticals
[Bentham Science]
日期:2014-12-30
卷期号:7 (2): 84-90
被引量:13
标识
DOI:10.2174/1874471007666141128160449
摘要
We described herein a simple and efficient microwave assisted synthesis of HYNIC analogues. Two different activated esters of HYNIC, the hydrazine protected with a trifluoroacetyl group (5) and the free hydrazine (6) were conjugated to the monoclonal antibody Nimotuzumab. Technetium-99m radiolabeling of Nimotuzumab was achieved with high efficiency using 5 and 6 derivates. The NHS-HYNIC-Tfa derivate allowed better labeling yields during longer times of preservation of the conjugated antibody.
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