Objective It is to discuss the relationship between the levels of CA125,CA199 and AFP of cirrhosis patients and ascites.Methods The levels of CA125, CA199 and AFP in serum of 217 cirrhosis patients and 50 healthy people were detected with radioimmunoassay.The levels of CA125,CA199 and AFP in ascites of 92 cases were detected at the same time.Results The CA125 levels in serum of cirrhosis patients were significantly higher than that of healthy control group,and were added by the worsened of cirrhosis.The levels of CA125 in serum of ascites patients were obviously raised,and compared with the same child classification without ascites patients,it had statistics value.With the addition of ascites quantity,the levels of CA125 in serum were upward trend.The levels of CA199 and AFP in cirrhosis patients rose slightly,but it wasn't clearly correlation with cirrhosis degree and ascites quantity.Conclusion The levels of CA125 in serum will be definitely consulting value in weighing the prognosis of cirrhosis patients and the ascites quantity.The levels of CA199 and AFP in cirrhosis patients rose slightly,but it wasn't clearly correlation with ascites quantity.