不确定意义的单克隆抗体病
精神障碍
多发性骨髓瘤
单克隆抗体病
副蛋白血症
单克隆
病因学
免疫学
医学
先证者
家庭聚集
病理
等离子体电池
单克隆抗体
遗传学
生物
疾病
抗体
突变
基因
作者
Nicola Bizzaro,P Pasini
出处
期刊:PubMed
日期:1990-01-01
卷期号:75 (1): 58-63
被引量:10
摘要
The etiology of monoclonal gammopathies remains unclear but familial occurrence of immunopathies seems to favor a possible hereditary background. In support of this view we report on a family in which five siblings had a monoclonal gammopathy. When MGUS was diagnosed in two of them, a family study was carried out: one sister died from multiple myeloma and four out of the seven living siblings were discovered to have a MGUS. The immunogenetic study (HLA) showed no direct correlation between haplotypes and the presence of the monoclonal protein. Nevertheless possible environmental exposure to viruses, chemicals and radiation was apparently excluded. This new report on familial involvement, the second ever reported for number of affected subjects, strongly supports the theory of genetic predisposition in the development of plasma cell dyscrasias.
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