Bioavailability of Potassium and Magnesium, and Citraturic Response from Potassium-Magnesium Citrate

No AccessJournal of Urology1 Feb 1991Bioavailability of Potassium and Magnesium, and Citraturic Response from Potassium-Magnesium Citrate Karl Koenig, Paulette Padalino, George Alexandrides, and Charles Y.C. Pak Karl KoenigKarl Koenig , Paulette PadalinoPaulette Padalino , George AlexandridesGeorge Alexandrides , and Charles Y.C. PakCharles Y.C. Pak View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)38330-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The bioavailability of potassium and magnesium, and the citraturic response were determined for the new compound, potassium-magnesium citrate, in 14 normal volunteers. Results were compared to those of potassium citrate and magnesium citrate. Each subject participated in 4 phases of study: potassium-magnesium citrate, potassium citrate, magnesium citrate and potassium chloride. After stabilization on a metabolic diet, each subject ingested a single load of a test medication followed by timed urine collections for the next 24 hours. Test loads included potassium-magnesium citrate (49mEq. potassium, 24.5mEq. magnesium and 73.5mEq. citrate), potassium citrate (50mEq.), potassium chloride (50mEq.) and magnesium citrate (25mEq.). Urinary potassium, magnesium and citrate were measured for each collection period. Potassium-magnesium citrate provided an equivalent potassium bioavailability as potassium citrate and potassium chloride, and a comparable magnesium bioavailability as magnesium citrate. However, it gave the highest citraturic response, since the cumulative increment in urinary citrate post-load was 129mg. daily for potassium-magnesium citrate, 105mg. daily for potassium citrate and 35mg. daily for magnesium citrate. Thus, potassium-magnesium citrate gave an optimum citraturic response in addition to providing absorbable potassium and magnesium. © 1991 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byZerwekh J, Odvina C, Wuermser L and Pak C (2018) Reduction of Renal Stone Risk by Potassium-Magnesium Citrate During 5 Weeks of Bed RestJournal of Urology, VOL. 177, NO. 6, (2179-2184), Online publication date: 1-Jun-2007.Ettinger B, Pak C, Citron J, Thomas C, Adams-Huet B and Vangessel A (2018) POTASSIUM-MAGNESIUM CITRATE IS AN EFFECTIVE PROPHYLAXIS AGAINST RECURRENT CALCIUM OXALATE NEPHROLITHIASISJournal of Urology, VOL. 158, NO. 6, (2069-2073), Online publication date: 1-Dec-1997.McLeod R and Churchill D (2018) Urolithiasis Complicating Inflammatory Bowel DiseaseJournal of Urology, VOL. 148, NO. 3 Part 2, (974-978), Online publication date: 1-Sep-1992. Volume 145 Issue 2 February 1991 Page: 330-334 Advertisement Copyright & Permissions© 1991 by The American Urological Association Education and Research, Inc.Keywordspotassiummagnesiumcitratespotassium chlorideMetrics Author Information Karl Koenig More articles by this author Paulette Padalino More articles by this author George Alexandrides More articles by this author Charles Y.C. Pak More articles by this author Expand All Advertisement PDF downloadLoading ...