Objective To analyze the anatomic characteristics of Fournier gangrene and to provide references in clinics.Methods The clinical data of 21 patients with Fournier gangrene from January 1997 to June 2011 were reviewed and discussed combined with literature analysis.Results One(1/21,4.76%) patient was died due to multiple organ failure induced by septicopyemia.Coexisting diabetes mellitus was found in three patients(3/21,14.29%).The infection of Fournier gangrene was extended along the superficial fascia in 17 patients(17/21,80.95%) with 1 patient(1/21,4.76 %) experiencing deep fascia infection.The most commonly found bacteria were streptococcal species,escherichia coli,staphylococcus,bacteroides,clostridium,et al.More than two organisms were cultured in 6 patients(6/21,28.57%).Conclusion Familiarity with the anatomic and path physiological characteristics of Fournier gangrene is important in the diagnosis and treatment of Fournier gangrene.