Effect of catalpol on brain energy metabolism in rats with permanent cerebral ischemia injury

Objective:To investigate the effect of catalpol on brain energy metabolism after permanent cerebral ischemia in rats.Method:Permanent cerebral ischemia was induced by permanent middle cerebral artery occlusion(pMCAO) in rats,and ischemic medication animals received intragastric administration once a day 3-14 days post-ischemia.Animals were killed at 14 days post ischemia.The inorganic phosphate assay method were used to evaluate the activity of Na+,K+-ATPase and Ca2+,Mg2+-ATPase of ischemic cortex.Result:There were significant difference of two indexes between sham operation group and model group(P0.01).And there were significant difference of two indexs between sham operation group and every treatment group(P0.05,P0.01).Conclusion:The mechanism of inhibiting apoptosis of rats brain cell from permanent cerebral ischemia by catalpol is well related to the increase of Na+,K+-ATPase and Ca2+,Mg2+-ATPase.