Determination of Total Aristolochic Acids and Aristolochic Acid I in Radix aristolochiae after Fermentation

With Radix aristolochiae as substrate,twenty fungi was test and 13 different fungi were found to be grown on it.Compare with that of the control,the AA Ⅰ content was decreased in those 13 fermentation product,and the AA Ⅰ content in 6 fermentation product was lower than 50%,compared with that of the control.Similarly,the TAA contents were also detected to be decrease.Among of them,the highest and lowest rate of decline was 46.76% and 7.61%,respectively.After statistical analysis,the ability to decompose the nephrotoxic substances in Radix aristolochiae of the 13 fungi was illustrated as follows(from the strong to the weak): F-1 F-2 F-5 F-6 F-8 F-13 F-4 F-11 F-3 F-9 F-10 F-12 F-7(the symbol of different fungi).Those results indicated that different fungi fermentation could efficient decrease the nephrotoxic components in Radix aristolochiae.