Effect of 654-2 on pneumon edema of rabbits caused by AD

Objective To investigate the effect of 654-2 on pneumon edema of rabbits caused by AD.Methods Copy the model of pneumon edema on rabbits by using of AD,and randomly divided the rabbits into the blank group with normal saline(100ml/kg,180d/min),the experiment group with AD and the treatment group with 654-2.In the experiment group,to give AD with 0.7mg/kg in addition to normal saline with the same dosage for the blank group(100ml/kg,180d/min).To give 654-2 with 20ml/kg for the treament group,dosage of normal saline and AD the same with the former.Monitor the changement of blood pressure(BP),respiration(R),lung coefficient and pathological change of the lung between prior-treatment and post-treatment.Results After the AD injection,the blood pressure increased remarkably,breathed rapidly and kept the state for a short time.Then the blood pressure reduced and respiration became weaker.654-2 reduced the blood pressure of rabbits(96.94 ±39.92mmHg vs experiment group135.47±25.74mmHg,P0.05),decreased the breath frequency remarkably(63±4.81/min vs experiment group 84.75 ±13.71/min,P0.01)and reduced lung coefficient(4.91±0.34 vs experiment group 6.59±2.57,P0.05).Conclusion Injecting 654-2 Achieved the therapeutic effect on pneumon edema of rabbits caused by AD.