苯丙氨酸
中子俘获
放射治疗
硼
放射化学
核医学
辐照
化学
医学
中枢神经系统
癌症研究
药理学
氨基酸
内科学
生物化学
物理
有机化学
核物理学
作者
Tsubasa Watanabe,Hiroki Tanaka,Satoshi Fukutani,Minoru Suzuki,Masahiro Hiraoka,Koji Ono
出处
期刊:Cancer Letters
[Elsevier]
日期:2016-01-01
卷期号:370 (1): 27-32
被引量:19
标识
DOI:10.1016/j.canlet.2015.10.004
摘要
Boron neutron capture therapy (BNCT) is a cellular-level particle radiation therapy that combines the selective delivery of boron compounds to tumour tissue with neutron irradiation. Previously, high doses of one of the boron compounds used for BNCT, L-BPA, were found to reduce the boron-derived irradiation dose to the central nervous system. However, injection with a high dose of L-BPA is not feasible in clinical settings. We aimed to find an alternative method to improve the therapeutic efficacy of this therapy. We examined the effects of oral preloading with various analogues of L-BPA in a xenograft tumour model and found that high-dose L-phenylalanine reduced the accumulation of L-BPA in the normal brain relative to tumour tissue. As a result, the maximum irradiation dose in the normal brain was 19.2% lower in the L-phenylalanine group relative to the control group. This study provides a simple strategy to improve the therapeutic efficacy of conventional boron compounds for BNCT for brain tumours and the possibility to widen the indication of BNCT to various kinds of other tumours.
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