Development of CAR-T Therapies: Case Histories of Significant Medical Advances
医学
作者
Amar Bhidé,Srikant M. Datar
出处
期刊:Social Science Research Network [Social Science Electronic Publishing] 日期:2021-01-01
标识
DOI:10.2139/ssrn.3863155
摘要
In 2017, the US Food and Drug Administration (FDA) approved an immunotherapeutic treatment, called CAR-T therapy, for two kinds of blood cancers — acute leukemia (ALL) and a lymphoma. We describe: 1) how CAR-T therapies (are believed to) work; 2) foundational advances and discoveries (through the 1980s); 3) the development of CAR-T therapy (during and after the 1990s); and 4) prospects for the 2020s.