铜绿假单胞菌
毒力
病菌
肺炎
生物
抗生素耐药性
微生物学
致病岛
抗生素
致病性
抗药性
基因
医学
细菌
遗传学
内科学
作者
Telma de Sousa,Michel Hébraud,Maria de Lurdes Enes Dapkevicius,Luís Maltez,José Eduardo López Pereira,Rosa Capita,Carlos Alonso‐Calleja,Gilberto Igrejas,Patrícia Poeta
标识
DOI:10.3390/ijms222312892
摘要
In recent years, the effectiveness of antimicrobials in the treatment of Pseudomonas aeruginosa infections has gradually decreased. This pathogen can be observed in several clinical cases, such as pneumonia, urinary tract infections, sepsis, in immunocompromised hosts, such as neutropenic cancer, burns, and AIDS patients. Furthermore, Pseudomonas aeruginosa causes diseases in both livestock and pets. The highly flexible and versatile genome of P. aeruginosa allows it to have a high rate of pathogenicity. The numerous secreted virulence factors, resulting from its numerous secretion systems, the multi-resistance to different classes of antibiotics, and the ability to produce biofilms are pathogenicity factors that cause numerous problems in the fight against P. aeruginosa infections and that must be better understood for an effective treatment. Infections by P. aeruginosa represent, therefore, a major health problem and, as resistance genes can be disseminated between the microbiotas associated with humans, animals, and the environment, this issue needs be addressed on the basis of an One Health approach. This review intends to bring together and describe in detail the molecular and metabolic pathways in P. aeruginosa's pathogenesis, to contribute for the development of a more targeted therapy against this pathogen.
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