Temperature-Compensating Fiber-Optic Surface Plasmon Resonance Biosensor

A temperature-compensating fiber-optic surface plasmon resonance (SPR) biosensor based on a Fabry-Perot (FP) interference is described and demonstrated in this letter. The sensing element includes an SPR measuring signal and an FP referencing signal, which appear on gold-coated multimode fiber and capillary, respectively. Because the FP sensing element is sensitive to temperature while insensitive to the refractive index, the referencing channel compensates for the impact of external ambient temperature and enhances the accuracy and reliability of the biosensor. The performance of the temperature-compensating SPR biosensor for accurate measurements is evaluated through the specific binding between Con A and RNase B under interference temperature. In addition, the design and fabrication of the temperature-compensating fiber SPR biosensor are cost effective and simple.