Anti-obesity effects of mogrosides extracted from the fruits of Siraitia grosvenorii (Cucurbitaceae)

In this study, total mogrosides extracted from Siraitia grosvenorii as well as, mogrosides V and IV were tested for their effects on pancreatic lipase in vitro. The body weight and food intake, abdominal and epididymal fats weight, and hepatic triacylglycerol (TG) and total cholesterol (TC) contents were evaluated using male C57BL/6 mice fed with a high fat diet (HF) with or without different concentrations of total mogrosides for 11 weeks. Plasma TG was also evaluated after oral administration of lipid emulsions to mice. The results showed that total mogrosides as well as, mogrosides V and IV (600 μg/ml) demonstrated good inhibitory effects on pancreatic lipase activity. In vivo, total mogrosides suppressed the increase in body weight, abdominal and epididymal fats weight, TG and TC content in mice’s liver; TG content in plasma was reduced at 1 to 3 h after oral administration of the lipid emulsion plus total mogrosides compared to those in the lipid emulsion groups. In addition, mice fed with HF plus 2% total mogrosides for 3 days had higher TG level in the feces compared to the HF group, which might be due to decreased  dietary fat absorption in the intestine caused by inhibition of pancreatic lipase activity.   Key words: Mogroside, pancreatic lipase, high diet, obesity, mice.