Serum Prealbumin and Retinol-Binding Protein Concentrations in Japanese-Type Familial Amyloid Polyneuropathy

Serum concentrations of prealbumin and retinol-binding protein were measured in 28 patients with Japanese-type familial amyloid polyneuropathy, 46 relatives and normal controls. Both the serum prealbumin and retinol-binding protein concentrations were significantly decreased in the patients when compared with normal controls. The mean serum levels of these proteins in the asymptomatic relatives were intermediate between controls and patients.