烯丙胺
内吞作用
戊二醛
化学
生物物理学
聚电解质
细胞
共价键
共域化
内体
细胞生物学
细胞质
微管
活力测定
生物化学
生物
色谱法
有机化学
聚合物
作者
Bing Wang,Yuying Zhang,Zhengwei Mao,Changyou Gao
标识
DOI:10.1002/mabi.201200182
摘要
Abstract The mechanism of the cellular uptake of polyelectrolyte microcapsules and its influences on the functions and toxicity of human SMCs are explored. The covalently assembled poly(allylamine hydrochloride)/glutaraldehyde microcapsules are easily ingested by SMCs mainly through macropinosis and caveolae‐mediated endocytosis pathways. The capsules mainly disperse in cytoplasm without colocalization in early endosomes and cell nucleus. The results of gene chips reveal substantial and profound alternation of cell phenotypes and functions. Uptake of the microcapsules cause a slight decrease of cell viability, but leads to significant changes in cytoskeleton organization, cell cycle, as well as cell adhesion and migration ability. magnified image
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