白细胞介素17
免疫学
细胞因子
T辅助细胞
T细胞
白细胞介素4
促炎细胞因子
生物
白细胞介素
自身免疫
细胞生物学
转化生长因子
炎症
免疫系统
作者
Elisabetta Volpe,Nicolas Servant,Raphaël Zollinger,Sofia Bogiatzi,Philippe Hupé,Emmanuel Barillot,Vassili Soumelis
摘要
Interleukin 17 (IL-17)-producing T helper 17 cells (T(H)-17 cells) have been described as a T helper cell subset distinct from T helper type 1 (T(H)1) and T(H)2 cells, with specific functions in antimicrobial defense and autoimmunity. The factors driving human T(H)-17 differentiation remain controversial. Using a systematic approach combining experimental and computational methods, we show here that transforming growth factor-beta, interleukin 23 (IL-23) and proinflammatory cytokines (IL-1beta and IL-6) were all essential for human T(H)-17 differentiation. However, individual T(H)-17 cell-derived cytokines, such as IL-17, IL-21, IL-22 and IL-6, as well as the global T(H)-17 cytokine profile, were differentially modulated by T(H)-17-promoting cytokines. Transforming growth factor-beta was critical, and its absence induced a shift from a T(H)-17 profile to a T(H)1-like profile. Our results shed new light on the regulation of human T(H)-17 differentiation and provide a framework for the global analysis of T helper responses.
科研通智能强力驱动
Strongly Powered by AbleSci AI