化学
卡宾
光催化
烷基
烯烃
卤化物
试剂
激进的
光化学
催化作用
钯
有机化学
组合化学
光催化
作者
You-Feng Han,Yongjie Huang,Hao Líu,Zhong‐Hua Gao,Chun-Lin Zhang,Song Ye
标识
DOI:10.1038/s41467-022-33444-0
摘要
Three-component carboacylation of simple alkenes with readily available reagents is challenging. Transition metal-catalysed intermolecular carboacylation works for alkenes with strained ring or directing groups. Herein, we develop a photoredox cooperative N-heterocyclic carbene/Pd-catalysed alkylacylation of simple alkenes with aldehydes and unactivated alkyl halides to provide ketones in good yields. This multicomponent coupling reaction features a wide scope of alkenes, broad functional group compatibility and free of exogenous photosensitizer or external reductant. In addition, a series of chlorinated cyclopropanes with one or two vicinal quaternary carbons is obtained when chloroform or carbon tetrachloride is used as the alkyl halide. The reaction involves the alkyl radicals from halides and the ketyl radicals from aldehydes under photoredox cooperative N-heterocyclic carbene/Pd catalysis.
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