表位
生物
生殖系
抗体
抗体库
抗原
剧目
遗传学
肽序列
计算生物学
互补决定区
基因
免疫球蛋白轻链
物理
声学
作者
Ellen Shrock,Richard T. Timms,Tomasz Kula,Elijah L. Mena,Anthony P. West,Rui Guo,I‐Hsiu Lee,Alexander A. Cohen,Lindsay G. A. McKay,Caihong Bi,Yumei Leng,Eric Fujimura,Felix Horns,Mamie Z. Li,Duane R. Wesemann,Anthony Griffiths,Benjamin E. Gewurz,Pamela J. Björkman,Stephen J. Elledge
出处
期刊:Science
[American Association for the Advancement of Science]
日期:2023-04-06
卷期号:380 (6640)
被引量:59
标识
DOI:10.1126/science.adc9498
摘要
Despite the vast diversity of the antibody repertoire, infected individuals often mount antibody responses to precisely the same epitopes within antigens. The immunological mechanisms underpinning this phenomenon remain unknown. By mapping 376 immunodominant “public epitopes” at high resolution and characterizing several of their cognate antibodies, we concluded that germline-encoded sequences in antibodies drive recurrent recognition. Systematic analysis of antibody-antigen structures uncovered 18 human and 21 partially overlapping mouse germline-encoded amino acid–binding (GRAB) motifs within heavy and light V gene segments that in case studies proved critical for public epitope recognition. GRAB motifs represent a fundamental component of the immune system’s architecture that promotes recognition of pathogens and leads to species-specific public antibody responses that can exert selective pressure on pathogens.
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