自愈水凝胶
韧性
材料科学
复合材料
对偶(语法数字)
化学工程
增韧
高分子化学
艺术
文学类
工程类
作者
Jiaqi Wang,Wanying Yang,Yutong Li,Xuerong Ma,Yuxin Xie,Guangyan Zhou,Shouxin Liu
出处
期刊:Gels
[Multidisciplinary Digital Publishing Institute]
日期:2024-07-19
卷期号:10 (7): 480-480
被引量:2
摘要
Hydrogels are widely used as excellent drug carriers in the field of biomedicine. However, their application in medicine is limited by their poor mechanical properties and softness. To improve the mechanical properties of hydrogels, a novel triple-network amphiphilic hydrogel with three overlapping crosslinking methods using a one-pot free-radical polymerization was synthesized in this study. Temperature-sensitive and pH-sensitive monomers were incorporated into the hydrogel to confer stimulus responsiveness, making the hydrogel stimuli-responsive. The successful synthesis of the hydrogel was confirmed using techniques, such as proton nuclear magnetic resonance spectroscopy (1H NMR), Fourier-transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD). In order to compare and analyze the properties of physically crosslinked hydrogels, physically–chemically double-crosslinked hydrogels, and physically–chemically clicked triple-crosslinked hydrogels, various tests were conducted on the gels’ morphology, swelling behavior, thermal stability, mechanical properties, and drug loading capacity. The results indicate that the triple-crosslinked hydrogel maintains low swelling, high mechanical strength, and good thermal stability while not significantly compromising its drug delivery capability.
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