材料科学
聚乳酸
脚手架
极限抗拉强度
磷灰石
生物活性玻璃
介孔材料
涂层
组织工程
表面改性
模拟体液
化学工程
纳米技术
复合材料
生物医学工程
聚合物
扫描电子显微镜
医学
生物化学
催化作用
化学
工程类
作者
Qiaohua Qiu,Xin Ding,Yanmin Wang,Yuhua Zheng,Lin-Fan Zhu,Ya Li,Tao Liu
标识
DOI:10.1016/j.mtcomm.2022.104098
摘要
Fabricating electrospun nanofibrous scaffolds from a combination of inorganic-organic hybrid materials is proposed as a versatile process in bone tissue engineering. However, to enhance or improve the interface issues of biphasic hybrid materials is still a challenge on how to balance the preparation conditions and physicochemical properties. Here, we designed the mussel-inspired surface assembly with copper-doped mesoporous bioactive glass (Cu-MBG) into polylactic acid (PLA) substance to enhance their mechanical and biological performances. The introduction of polydopamine (PDA) into the Cu-MBG matrix was to retain the mesostructure and improve physiological stability. Also, the nanofibrous hybrid scaffolds with/without PDA (i.e., PLA/[email protected], PLA/Cu-MBG) were fabricated to evaluate the microstructural, mechanical properties, and biological features. The PDA modification in such fibrous structure could not only adjust the physicochemical properties and surface hydrophilicity, but also enhance its tensile strength. PLA/[email protected] exhibited strength of 5.57 MPa and elongation at break of 65.75%, showing an improvement over PLA/Cu-MBG. Extensive in vitro biological evaluation showed that the PLA/[email protected] scaffold exhibited many superior properties such as excellent apatite-formation ability, and enhanced cell viability compared with PLA/Cu-MBG scaffold. The mussel-inspired method provided a facile and effective strategy to combine the merits of organic/inorganic phase in one system, demonstrating its potential application in bone tissue regeneration.
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