Transdermal Delivery of Baicalin Based on Bio‐Vesicles and Its Efficacy in Antiaging of the Skin

ABSTRACT Objective To develop a stable and efficient delivery system for baicalin, a flavonoid with potential antioxidant and antiaging properties, to overcome its limitations in solubility, stability, and skin permeability. Methods Baicalin was encapsulated using ATP synthase molecular motor technology into bio‐vesicles derived from yeast/bacillus cell membranes, forming “motor baicalin” (MB). The liposome baicalin (LB), baicalin raw material (BRM), and bio‐vesicles were used for comparison. The stability, transdermal penetration, and antioxidant activity of MB, LB, BRM, and bio‐vesicles were evaluated through in vitro and in vivo tests. Results MB formed a stable core‐shell structure, significantly enhancing the water solubility and long‐term stability of baicalin. The tests confirmed superior transdermal penetration and antioxidant activity of MB, evidenced by increased expression of SOD, CAT, and GSH‐Px enzymes and improved cell proliferation and migration. Clinical trials demonstrated significant reductions in wrinkle depth and improvements in skin elasticity. Conclusion This study presents a promising approach to improving the stability and transdermal delivery of baicalin. MB showcases potent antioxidant and antiaging properties, making it a valuable component in skincare products.