Hydroxychloroquine inhibits the PI3K/AKT pathway in synovial fibroblasts of rheumatoid arthritis and alleviates collagen-induced arthritis in mice

Our molecular docking studies indicate KIT, SRC, and PIK3A may potentially serve as the targets of Rac-HCQ in RA. These findings reveal the potential of Rac-HCQ to modulate the functions of RA-FLS and mitigate CIA manifestations, principally through its interaction with the pathway PI3K/AKT.