LncRNA EMBP1 sponges miR-454-3p to upregulate IRF1 and activate NLRP3-mediated chondrocyte pyroptosis to drive osteoarthritis progression

In OA, EMBP1 acts as a sponge for miR-454-3p, inhibiting its negative regulatory effect on IRF1 and exacerbating NLRP3-mediated chondrocyte pyroptosis. Furthermore, EMBP1/miR-454-3p/IRF1-mediated pyroptosis may be integrated into the broader PANoptosis process, interacting with apoptosis and necrosis to influence OA progression.