Targeting the crosstalk between glutamine metabolism and tumor immune microenvironment for lung cancer immunotherapy (2/2025)

This image represents the key concepts of our paper on glutamine metabolic reprogramming in the immune microenvironment of lung tumors. The central figure symbolizes a lung with tumor. Red cells on the right denote lung cancer cells, while the other cells represent normal lung cells and immune cells. The candy-shaped objects symbolize glucose, and the spherical shapes represent glutamine. This visual representation highlights the metabolic processes of glucose and glutamine within the lung tumor immune microenvironment. The whole picture demonstrates that lung cancer cells exhibit a higher affinity for glutamine uptake compared to immune cells, which offers novel insights for developing lung cancer immunotherapy strategies.