New Insights into the Pharmacology and Biodistribution of Gadolinium-based Contrast Agents

HomeRadiologyVol. 309, No. 1 PreviousNext Reviews and CommentaryEditorialNew Insights into the Pharmacology and Biodistribution of Gadolinium-based Contrast AgentsMichael F. Tweedle Michael F. Tweedle Author AffiliationsFrom the Department of Radiology, Ohio State University, 495 W 12th Ave, Columbus, OH 43210.Address correspondence to the author (email: [email protected]).Michael F. Tweedle Published Online:Oct 24 2023https://doi.org/10.1148/radiol.232619MoreSectionsFull textPDF ToolsAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinked In References1. McDonald RJ, Levine D, Weinreb J, et al. Gadolinium retention: a research roadmap from the 2018 NIH/ACR/RSNA Workshop on Gadolinium Chelates. Radiology 2018;289(2):517–534. Link, Google Scholar2. Le Fur M, Moon BF, Zhou IY, et al. Gadolinium-based contrast agent biodistribution and speciation in rats. Radiology 2023;309(1):e230984. Google Scholar3. Lohrke J, Frisk AL, Frenzel T, et al. Histology and gadolinium distribution in the rodent brain after the administration of cumulative high doses of linear and macrocyclic gadolinium-based contrast agents. Invest Radiol 2017;52(6):324–333. Crossref, Medline, Google Scholar4. McDonald RJ, McDonald JS, Dai D, et al. Comparison of gadolinium concentrations within multiple rat organs after intravenous administration of linear versus macrocyclic gadolinium chelates. Radiology 2017;285(2):536–545. Link, Google Scholar5. Kobayashi M, Levendovszky SR, Hippe DS, et al. Comparison of human tissue gadolinium retention and elimination between gadoteridol and gadobenate. Radiology 2021;300(3):559–569. Link, Google Scholar6. Bussi S, Coppo A, Botteron C, et al. Differences in gadolinium retention after repeated injections of macrocyclic MR contrast agents to rats. J Magn Reson Imaging 2018;47(3):746–752. Crossref, Medline, Google Scholar7. Bussi S, Coppo A, Bonafè R, et al. Gadolinium clearance in the first 5 weeks after repeated intravenous administration of gadoteridol, gadoterate meglumine, and gadobutrol to rats. J Magn Reson Imaging 2021;54(5):1636–1644. Crossref, Medline, Google Scholar8. Frenzel T, Ulbrich H-F, Pietsch H. The macrocyclic gadolinium-based contrast agents gadobutrol and gadoteridol show similar elimination kinetics from the brain after repeated intravenous injections in rabbits. Invest Radiol 2021;56(6):341–347. Crossref, Medline, Google Scholar9. Lorusso V, Arbughi T, Tirone P, de Haën C. Pharmacokinetics and tissue distribution in animals of gadobenate ion, the magnetic resonance imaging contrast enhancing component of gadobenate dimeglumine 0.5 M solution for injection (MultiHance). J Comput Assist Tomogr 1999;23(Suppl 1):S181–S194. Crossref, Medline, Google ScholarArticle HistoryReceived: Sept 28 2023Revision requested: Oct 3 2023Revision received: Oct 4 2023Accepted: Oct 9 2023Published online: Oct 24 2023 FiguresReferencesRelatedDetailsRecommended Articles RSNA Education Exhibits RSNA Case Collection Vol. 309, No. 1 Metrics Altmetric Score PDF download