立体中心
全合成
邻接
天然产物
醛
环加成
化学
立体化学
二醇
催化作用
对映选择合成
有机化学
作者
Sen Zhang,Songming Zhang,Fan Yang,Xuhai Zhang,Jingwen Chen,Chaofan Jin,Sisi Chen,Liang Wang,Quan Zhang,Yue Chen
标识
DOI:10.1002/anie.202313186
摘要
The total synthesis of the proposed structure of anti-glioblastoma natural product neaumycin B was achieved in 22 longest linear steps. The synthesis features an in situ-generated HCl-mediated [6,6]-spiroketalization, a combination of novel Krische Ir-catalyzed crotylation, Marshall Pd-catalyzed propargylation, Fürstner Ni-catalyzed regio- and enantio-selective vicinal monoprotected diol formation, Brown crotylation and asymmetric halide-aldehyde cycloaddition, so as to establish the challenging contiguous stereocenters.
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