Metabolic elasticity: A new measure of age

Promoting healthy aging is contingent on understanding the underlying mechanisms for the age-associated decline in metabolic physiology. Through developing a novel concept of “metabolic elasticity” to evaluate metabolic adaptability in response to cyclical changes in energy balance, Zhou et al. present an impactful gauge of metabolic health that is particularly relevant to aging. Promoting healthy aging is contingent on understanding the underlying mechanisms for the age-associated decline in metabolic physiology. Through developing a novel concept of “metabolic elasticity” to evaluate metabolic adaptability in response to cyclical changes in energy balance, Zhou et al. present an impactful gauge of metabolic health that is particularly relevant to aging. Deciphering the decline of metabolic elasticity in aging and obesityZhou et al.Cell MetabolismAugust 24, 2023In BriefWe designed a “metabolic elasticity” scoring system measuring an organism’s capacity to cope with and recover from metabolic fluctuations. With age and obesity, this elasticity notably diminishes, shedding light on the fundamental causes of metabolic degradation in these conditions. Full-Text PDF